The 18th International Symposium on Molecular and Neural Mechanisms

of Taste and Olfactory Perception

(ISMNTOP2019)

 (in conjunction with YRUF2019/AISCRIB2019)

 

 

 

Hosted by

Kyushu University, Research and Development Center for Five-Sense Devices

(九州大学・五感応用デバイス研究開発センター)

 

Acknowledgements

The organizers of the ISMNTOP extends special thanks and appreciation to the following organizations and companies for their generous support of the meeting.

  Japanese Association for the study of taste and smell (日本味と匂学会)

  Umami Manufacturer’s Association of Japan (日本うま味調味料協会)

  Ajinomoto Co., Inc. (味の素株式会社)

 

 

Organizer

Yuzo Ninomiya (Research and Development Center for Five-Sense Devices, Kyushu University)

 

Organizing Committee

Yuzo Ninomiya (Kyushu University, Fukuoka, Japan)

Toshiro Matsui (Kyushu University, Fukuoka, Japan)

Kiyoshi Toko (Kyushu University, Fukuoka, Japan)

Masahiro Yamaguchi (Kochi University, Kochi, Japan)

Takeshi Imai (Kyushu University, Fukuoka, Japan)

Yoko Ogiwara (Ajinomoto Co. Inc., Kawasaki, Japan)

Noriatsu Shigemura (Kyushu University, Fukuoka, Japan)

Keiko Yasumatsu (Tokyo Dental College, Tokyo, Japan)

Ryusuke Yoshida (Okayama University, Okayama, Japan)

 

 

November 2nd, Saturday -----------------------------------------------------------------------------------------

 

■ Opening remarks  12:50 - 13:00    Yuzo Ninomiya (Kyushu Univ)

 

■ Special lecture I    13:00 - 13:40  (Invited talk)

[Chair: Satoshi Wakisaka (Osaka Univ)]

The Search for the Neural Basis of Behavioral Responsiveness to Maltodextrin Taste and the Importance of Central Olfactory Bulb Connections in the Maintenance of Positive Affective Gustatory Function

Alan C. Spector

Department of Psychology and Program in Neuroscience, Florida State University, USA

 

Break 13:40 - 13:50 

 

 

Session I    13:50 16:30

Asian International Symposium on Chemo-Reception and Ingestive Behavior 2019 (AISCRIB2019)

[Chair: Mamiko Ozaki (Kobe Univ), Hiroo Imai (Kyoto Univ)]

 

IS1-1  13:50 – 14:20 (Invited talk)

Cross-modal interactions initiate Drosophila feeding

Seok Jun Moon

Department of Oral Biology, Taste Research Center, Yonsei University College of Dentistry

 

IS1-2  14:20 – 14:50 (Invited talk)

Disinhibition of rewarding dopamine neurons causes cognitive bias

Nobuhiro Yamagata, Takahiro Takahashi, Rino Ichikawa, Hiromu Tanimoto

Graduate School of Life Sciences, Tohoku University, Japan

 

IS1-3  14:50 – 15:15

An evolutionary aspect of the chemical defense of plant: ER-body system in brassica plant decreases feeding motivation in insect via chemosensory system

Mamiko Ozaki

Department of Biology, Graduate School of Science, Kobe University, Nada, Kobe, Japan

 

IS1-4  15:15 – 15:40

A genetic tool to label almost all subpopulation of postsynaptic neurons directly-connected to sugar-responsive sensory neurons in Drosophila

Takaaki Miyazaki1, 2, 3, Tzu-Yang Lin1, Chi-hon Lee1, Mark Stopfer1, Kei Ito2, Emiko Suzuki3, 4

1NIH-NICHD, 2IMCB, Univ. Tokyo, 3National Institute of Genetics, Japan, 4SOKENDAI

 

IS1-5  15:40 – 16:05

The central mechanisms for mediating salt-induced hypertension

Kengo Nomura1, Takeshi Y. Hiyama1,2, Masaharu Noda1,2,3

1Division of Molecular Neurobiology, National Institute for Basic Biology, 2School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 3Research Center for Cell Biology, Institute of Innovative Research, Tokyo Institute of Technology

 

IS1-6  16:05 – 16:30 (Invited talk)

Constant-rate delivery of glucagon like peptide-1 receptor agonist alters sucrose within-meal licking behavior in male rats

Tadashi Inui1, Kellie Hyde1, Ginger Blonde1, Clare Mathes2, Alan Spector1

1Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, USA, 2Department of Psychology and Program in Neuroscience, Baldwin Wallace University, Berea, OH, USA

 

Break 16:30 - 16:50

 

 

Session II    16:50 18:30

Memorial Session for Dr. Takayuki Marui

[Chair: Yuzo Ninomiya (Kyushu Univ), Kumiko Sugimoto (Tokyo Med Dent Univ)]

 

IS2-1+IS2-2  16:50 – 17:10

Session overview

Yuzo Ninomiya

IS2-2  

In Memory of Dr. Takayuki Marui

John Caprio

(Lousiana State Univ. Baton Rouge, USA)

[Narrated power point presentation with the help of Noritaka Sako (Asahi Univ)]

 

IS2-3  17:10 – 17:25 (Invited talk)

Remembrance of Takayuki Marui

Takashi Yamamoto

Kio University, Nara, Japan

 

IS2-4  17:25 – 17:40 (Invited talk)

Universe of amino acid chemical senses in vertebrate including humans in collaboration with Dr. Takayuki Marui

Kunio Torii

Torii Nutrientstasis Institute, Inc. Japan

 

IS2-5  17:40 – 17:55 (Invited talk)

Remembering the late Dr. Takayuki Marui from over 40 years of joint research

Sadao Kiyohara

Emeritus Professor, Kagoshima University

 

IS2-6  17:55 – 18:25 (Invited talk)

A fish taste receptor opened the way for structural biology of taste perception

Atsuko Yamashita

Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan

 

A silent prayer

 

 

■ Poster Session & Social Gathering   18:40 – 21:00

@ Collabo-Station II, 1F Communication lounge, Kyushu University

 

 

 

 November 3rd, Sunday ----------------------------------------------------------------

 

Session III    9:30 11:10

Olfaction

[Chair: Masahiro Yamaguchi (Kochi Univ), Takeshi Imai (Kyushu Univ)]

 

IS3-1  9:30 – 9:55

Long-term modification of the olfactory circuit in C. elegans life span

Manabi Fujiwara, Hiroshi Wada, Takeshi Ishihara

Faculty of Science, Kyushu University, Japan

 

IS3-2  9:55 – 10:20

Cell-type-specific patterned activities specify gene expression patterns for olfactory circuit formation

Ai Nakashima1, Naoki Ihara1, Yuji Ikegaya1,2, Haruki Takeuchi1

1Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan, 2Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka, Japan

 

IS3-3  10:20 – 10:45

Widespread inhibitory responses in the mouse olfactory sensory neurons in vivo

Shigenori Inagaki1, Ryo Iwata2, Takeshi Imai1

1Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2RIKEN Center for Developmental Biology, Kobe, Japan.

 

IS3-4  10:45 – 11:10

Association of Odor Signals with Subsequent Behavioral Scene Signals in Piriform Cortex

Yuta Tanisumi1,2, Kazuki Shiotani1,2, Keiji Miura3, Junya Hirokawa1, Yoshio Sakurai1, Kensaku Mori4, Hiroyuki Manabe1

1Laboratory of Neural Information, Graduate School of Brain Science, Doshisha University, Kyoto, Japan, 2Research Fellow of the Japan Society for the Promotion of Science, Tokyo, Japan, 3School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan, 4The University of Tokyo, Tokyo, Japan

 

 

Break  11:10 - 11:25

 

 

■ Special lecture II    11:25 - 12:05  (Invited talk)

[Chair: Masahiro Yamaguchi (Kochi Univ), Takeshi Imai (Kyushu Univ)]

New strategies for understanding the organization and dynamics of glomerular odor maps

Matt Wachowiak

Department of Neurobiology and Anatomy, University of Utah School of Medicine

 

 

Lunch  12:05-13:00

 

 

■ Special lecture III    13:00 - 13:40   (Invited talk)

[Chair: Ken Iwatsuki (Tokyo Univ Agri)]

Gingival solitary chemosensory cells serve as immune sentinels to protect against periodontitis

Xin Zheng1,2, Marco Tizzano1, Kevin Redding1, Jinzhi He2, Xian Peng2, Peihua Jiang1, Xin Xu2, Xuedong Zhou2, Robert Margolskee1

1Monell Chemical Senses Center, Philadelphia, PA, USA, 2State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China

 

 

Break 13:40 – 13:50

 

■ Session IV    13:50 – 16:50

Chemosensory signaling

[Chair: Mizuho Kido (Saga Univ), Akiyuki Taruno (Kyoto Pref Univ Med)]

 

IS4-1  13:50 – 14:20 (Invited talk)

Functional interaction between TRPV3 and anoctamin 1 in keratinocytes

Makoto Tominaga1,2

1Division of Cell Signaling, National Institute for Physiological Sciences, 2Thermal Biology Group, Exploratory Research Center on Life and Living Systems

 

IS4-2  14:20 – 14:40

Changes of TRPV4 distribution in labial mucosa of Xerostomia Patients with unpleasant burning sensation

Reiko U. Yoshimoto1,2,3, Reona Aijima4, Yukiko Oyama5, Junko Yoshizumi5, Tomoko Kitsuki5, Yasuyoshi Ohsaki1, Atsushi Danjo4, Yoshio Yamashita4, Tamotsu Kiyoshima2, Mizuho A. Kido1

1Division of Histology and Neuroanatomy, Dept. of Anatomy and Physiology, Fac. Med., Saga Univ., 2Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, 3Dept. of Periodontology, Grad. Sch. of Dent. Sci., Kyushu Univ., 4Dept. of Oral and Maxillofacial Surgery, Fac. Med., Saga Univ., 5Dept. of Oral and Maxillofacial Surgery, Grad. Sch. of Dent. Sci., Kyushu Univ.

 

IS4-3  14:40 – 15:05

Decreased sensitivity of the bitter taste receptor TAS2R16 to β-glucosides in the dietary specialized bamboo lemurs

Akihiro Itoigawa1, Febrizio Fierro2, Morgan E. Chaney3, Takashi Hayakawa4, Anthony J. Tosi3, Masha Y. Niv2, Hiroo Imai1

1Primate Research Institute, Kyoto University, Japan, 2The Hebrew University, Israel, 3Department of Anthropology, Kent State University, USA, 4Faculty of Environmental Earth Science, Hokkaido University, Japan

 

 

Break 10min

 

 

IS4-4  15:15 – 15:40

Generation of endocrine cells using organoid culture system

Ken Iwatsuki

Dept. Nutritional Science and Food Safety, Tokyo Univ. Agriculture, Tokyo, Japan

 

IS4-5  15:40 – 16:10 (Invited talk)

Cells and transduction of sodium taste at the periphery

Akiyuki Taruno1,2, Kengo Nomura1

1Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan. 2PRESTO, JST, Kawaguchi, Saitama, Japan.

 

IS4-6  16:10 - 16:30

Contribution of SGLTs to sugar sensing as T1R-independent mechanisms in mouse gustatory tissues

Keiko Yasumatsu1, 2, Tadahiro Ohkuri3, Shusuke Iwata2, 3, Robert. F. Margolskee4, Yuzo Ninomiya2, 3, 4

1Oral Health Science Center, Tokyo Dental College, 2Div. Sensory PhysiologyMedical Application Sensing, Research and Development Center for Five-Sense Devices, Kyushu Univ., 3Sect. Oral Neuroscience, Grad. Sch. of Dent., Kyushu Univ., 4Monell Chemical Senses Center

 

IS4-7  16:30 – 16:50

Signaling cascade for the sweet suppressive effect of leptin

Ryusuke Yoshida1, Robert F. Margolskee2, Yuzo Ninomiya2,3

1Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Japan, 2Monell Chemical Senses Center, PA, USA, 3Division of Sensory Physiology, Research and Development Center for Five-Sense Device, Kyushu University, Japan

 

■ Closing remarks  16:50 -       Satoshi Wakisaka (Osaka Univ)

 


[Discussants:

Alan C. Spector (Florida State Univ), Robert F. Margolskee (Monell Chem Senses Center), Matt Wachowiak (Univ Uta), Seok Jun Moon (Yonsei Univ), Yamamoto T (Kio Univ), Sugimoto K (Tokyo Med Dent Univ), Kiyohara S (Kagoshima Univ), Tominaga M (Okazaki Inst for Integ Biosci), Torii K (Torii Nutrient-stasis Inst Inc), Wakisaka S (Osaka Univ), Inui T (Florida State Univ), Inui C (Osaka Univ), Ozaki M (Kobe Univ), Tanimoto H (Tohoku Univ), Taruno A (Kyoto Pref Univ of Med), Nomura K (Kyoto Pref Univ of Med), Toyono T (Kyushu Dent Coll), Iwatsuki K (Tokyo Univ Agricul), Imai H (Kyoto Univ), Kido M (Saga Univ), Goto T (Tokyo Dent Coll), Sako N (Asahi Univ), Yasuo T (Asahi Univ), Yamashita A (Okayama Univ), Kawai T (NARO), Sakai N (Tohoku Univ), Alexandre R (Tohoku Univ), Miyazaki T (NIH-NICHD), Matsumoto K (Kyoto Pharm Univ), Hashimoto K (Kumamoto Univ), Matsui T (Kyushu Univ), Toko K (Kyushu Univ), Imai T (Kyushu Univ), Yamaguchi M (Kochi Univ), Fujiwara M (Kyushu Univ), Nakashima A (Univ Tokyo), Inagaki S (Kyushu Univ), Tanisumi Y (Doshisha Univ), Kohmura M (Ajinomoto Co Inc), Ogiwara Y (Ajinomoto Co Inc), Maruyama Y (Ajinomoto Co Inc), Masuzawa Y (Ajinomoto Co Inc), Taruno E (Suntory Global Innovation Center Ltd), Jyotaki M (JT), Nagai H (Zensho Holdings)]

 


 

Poster Session

 

ISP01

Correlation analysis of sister mitral and tufted cells

Yusuke Tsuno1, 2, Matt Wachowiak1

1Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, USA,2Department of Integrative Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

 

ISP02

Feeding-related neuromodulator expression and the role of appetite regulating signals on olfactory feeding behavior in mice

Md Monjurul Ahasan1, Yasuko Nogi2, Yoshihiro Murata1, Mutsuo Taniguchi1, Chiori Ijichi2, Masahiro Yamaguchi1

1Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan, 2Institute of Food Sciences and Technologies, Ajinomoto Co., Japan

 

ISP03

Role of olfactory tubercle in the weaning process of neonatal mice

Masahiro Yamaguchi, Yasutaka Chikuda

Department of Physiology, Kochi Medical School, Kochi University, Kochi, Japan

 

ISP04

BMP signaling via LIMK regulates developmental remodeling of mitral cells dendrites

Shuhei Aihara, Satoshi Fujimoto, Takeshi Imai

Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

 

ISP05

Spontaneous activity generated within the olfactory bulb establishes the discrete wiring of mitral cell dendrites

Satoshi Fujimoto, Marcus Leiwe, Takeshi Imai

Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

 

ISP06

Spontaneous and evoked activity in the awake neonatal mouse olfactory bulb

Marcus Leiwe1, Satoshi Fujimoto1, Marlieke Van Erp1, 2, Takeshi Imai1

1Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2School for Mental Health and Neurosciences, Maastricht University, Netherlands

 

ISP07

Comparing the effects of color and shape on olfactory perception in humans

Jiang Yinan1, Ikuhiro Kida2, Shuta Maekawa1, Nobuyuki Sakai1

1Tohoku University, 2NICT

 

ISP08

Transient receptor potential vanilloid 4 in type IV basal cells mediates sour taste sensing via type III taste cell differentiation

Kenjiro Matsumoto1, Ken Iwatsuki2, Makoto Tominaga3, Kazuki Nagasawa4, Shinichi Kato1

1Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, 2Department of Nutritional Science and Food Safety, Tokyo University of Agriculture, 3Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, 4Department of Environmental Biochemistry, Kyoto Pharmaceutical University

 

ISP09

Sour suppressing effects by experienced flavors

Takayuki Kawai, Yuko Kusakabe, Yukino Ogawa

Food Research Institute, NARO, Tsukuba, Japan

 

ISP10

Expression of umami taste receptors in the taste bud cells of chickens, and behavioral responses to umami taste in chickens

Yuta Yoshida1,2, Zhonghou Wang2, Kayvan F. Tehrani2, Emily G. Pendleton2, Luke J Mortensen2, Shotaro Nishimura1, Shoji Tabata1, Hong-Xiang Liu2, Fuminori Kawabata3

1Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, Fukuoka, Japan, 2Regenerative Bioscience Center, Department of Animal and Dairy Science, University of Georgia, Georgia, USA, 3Physiology of Domestic Animals, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan

 

ISP11

Analysis of expression of GLP-1R after daily intake of sweet solution in chickens

Yuki Matsui, Fuminori Kawabata, Momoko Higashida, Shotaro Nishimura, Shoji Tabata

Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, Fukuoka, Japan

 

ISP12

The effect of Adrenomedullin on chorda tympani nerve responses to sugars via T1rs-independent pathway in mice

Shusuke Iwata1,2, Mayuko Inoue3, Ryusuke Yoshida4, Yuzo Ninomiya2,5

1Sect Oral Neurosci, Grad Sch Dent Sci, Kyushu Univ., 2Div of Sensory Physiologymedical application sensing, R&D Cent for Five-Sense Device, Kyushu Univ., 3OBT Res Cent, Grad Sch Dent Sci, Kyushu Univ., 4Dept. of Oral Physiol., Grad. Sch. of Med., Dent., and Pharm. Sci., Okayama Univ., 5Monell Chemical Senses Center

 

ISP13

Insulin - mTOR signaling regulate taste bud organoid growth

Shingo Takai1, Robert F. Margolskee2, Peihua Jiang2, Yuzo Ninomiya2, 3, Noriatsu Shigemura1, 3

1Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, 2Monell Chemical Senses Center, 3R and D Center for Five-Sense Devices, Kyushu University

 

ISP14

A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemurs

Akihiro Itoigawa1, Takashi Hayakawa2, Nami Suzuki-Hashido3, Hiroo Imai1

1Primate Research Institute, Kyoto University, Japan, 2Faculty of Environmental Earth Science, Hokkaido University, Japan, 3Chubu University Academy of Emerging Sciences, Japan

 

ISP15

Functional analysis of Myod1 in the transcriptional regulation of mouse Tas1r1 gene

Takashi Toyono1, Yui Obikane2, Kae Matsuyama1, Shinji Kataoka1, Mitsushiro Nakatomi1, Ryuji Hosokawa2, Yuji Seta2

1Division of Anatomy, Kyushu Dental University, 2Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University

 

ISP16

Histological identification of the range of primary gustatory cortex in using the fluorescent retrograde neuronal tracer in rats

Koji Hashimoto1, Alan C. Spector2

1Kumamoto University, Faculty of Life Sciences, Kumamoto, Japan, 2Florida State University, Department of Psychology and Program in Neuroscience, Tallahassee, FL, USA

 

ISP17

Surgical Removal of Olfactory Bulb-Brain Connections Blunts Licking Behavior to Preferred, But Not Avoided Solutions

Inui-Yamamoto C1,2, Blonde GD2, Schmid F2, Inui T2, Schier LA3, Spector AC2

1Department of Oral Anatomy & Development Biology, Osaka University Graduate School of Dentistry, Japan, 2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL, USA., 3Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA